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Detection of Viral RNA by Fluorescence in situ Hybridization FISH
Published on: May 5, 2012
Who Regulates Whom? An Overview of RNA Granules and Viral Infections
Natalia Poblete-Durán1, Yara Prades-Pérez2, Jorge Vera-Otarola3
1Molecular and Cellular Virology Laboratory, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Independencia 1027, Santiago, 8389100, Chile. natalia.poblete.duran@gmail.com.
Abstract:
After viral infection, host cells respond by mounting an anti-viral stress response in order to create a hostile atmosphere for viral replication, leading to the shut-off of mRNA translation (protein synthesis) and the assembly of RNA granules. Two of these RNA granules have been well characterized in yeast and mammalian cells, stress granules (SGs), which are translationally silent sites of RNA triage and processing bodies (PBs), which are involved in mRNA degradation. This review discusses the role of these RNA granules in the evasion of anti-viral stress responses through virus-induced remodeling of cellular ribonucleoproteins (RNPs).
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