Related Experiment Video
Updated: Mar 18, 2026
05:22
Iris Fixation via External Pentagram Suturing
Published on: May 5, 2022
2.0K
Risk factors for intraoperative floppy iris syndrome: a prospective study
I P Chatziralli1, V Peponis1, E Parikakis1
12nd Department of Ophthalmology, Ophthalmiatrion Athinon, Athens, Greece.
Eye (London, England)
|July 2, 2016
Summary
This study identified new risk factors for intraoperative floppy iris syndrome (IFIS) during cataract surgery. Beyond alpha-blockers, benzodiazepines, quetiapine, finasteride, and hypertension are now linked to IFIS.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Intraoperative floppy iris syndrome (IFIS) is a complication during cataract surgery.
- Alpha-blocker medications are known risk factors for IFIS.
Purpose of the Study:
- To identify additional risk factors for IFIS in patients undergoing phacoemulsification.
- To evaluate the association of various medications and clinical factors with IFIS.
Main Methods:
- A prospective study of 1274 patients undergoing phacoemulsification.
- Data collected included ophthalmological conditions, eye length, demographics, clinical data, and medications.
- Univariate and multivariate logistic regression analyses were performed.
Main Results:
- IFIS occurred in 4.9% of patients.
- Independent risk factors for IFIS included tamsulosin, alfuzosin, terazosin, benzodiazepines, quetiapine, finasteride, and hypertension.
- Male sex, rivastigmine, and short axial length showed associations in univariate analysis.
Conclusions:
- Benzodiazepines, quetiapine, finasteride, and hypertension are potential risk factors for IFIS, in addition to alpha-blockers.
- Short axial length and rivastigmine require further investigation for their association with IFIS.
Related Concept Videos
01:28Angle Closure Glaucoma: Treatment
1.6K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
01:25Glaucoma: Overview
1.6K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.6K
01:27Open Angle Glaucoma: Treatment
1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K