Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Opioid Receptors: Overview01:22

Opioid Receptors: Overview

6.1K
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
6.1K
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

897
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
897
Hormonal Regulation01:33

Hormonal Regulation

36.7K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
36.7K
Drug Elimination by Renal Route: Tubular Secretion01:15

Drug Elimination by Renal Route: Tubular Secretion

3.7K
Once the process of glomerular filtration is completed, blood carrying unfiltered drug molecules traverses through efferent arterioles and makes its way into the peritubular capillaries in the proximal tubule. A variety of carriers play a pivotal role in actively secreting drugs from these peritubular capillaries into the tubular fluid. The organic anion transporter transfers acidic drugs, against an electrochemical gradient, from the peritubular capillaries into the renal tubule cells and...
3.7K
Renal Corpuscle01:20

Renal Corpuscle

8.3K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
8.3K
Renal Drug Excretion: Overview01:15

Renal Drug Excretion: Overview

919
As primary excretory organs, the kidneys maintain homeostasis by removing waste substances from the bloodstream. They comprise over a million units called nephrons, which serve as the kidney's functional units.
A nephron consists of two primary structures: the renal corpuscle and the renal tubule. The renal corpuscle contains the glomerulus, a network of capillaries where the first step of renal excretion, glomerular filtration, occurs. Blood pressure forces water, ions, and small molecules...
919

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dissociation between metabolic improvements and mitochondrial transcriptional changes following exercise training in women with polycystic ovary syndrome.

American journal of physiology. Endocrinology and metabolism·2026
Same author

Impact of diet and exercise in growth restricted female rats on nephron endowment in male fetuses.

Experimental physiology·2025
Same author

Metabolic crosstalk between skeletal muscle and cartilage tissue: insights into myokines in osteoarthritis.

Molecular biology reports·2025
Same author

Neuromuscular electrical stimulation enhances glycemic control and carbohydrate utilization in sedentary, predominantly Hispanic overweight or obese individuals with hyperglycemia.

European journal of applied physiology·2025
Same author

Mitochondrial Oxygen Consumption and Immunocytochemistry of Human Dental Pulp Stem Cell Following 808 nm PBM Therapy: A 3D Cell Culture Study.

Journal of biophotonics·2025
Same author

Effects of Multiple Near-Infrared LEDs (700, 850, and 980 nm) CW-PBM on Mitochondrial Respiration and Gene Expression in MG63 Osteoblasts.

Journal of biophotonics·2025

Related Experiment Video

Updated: Mar 18, 2026

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
08:46

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

Published on: September 1, 2015

10.3K

Cannabinoid receptors in the kidney.

Deanne H Hryciw1, Andrew J McAinch

  • 1aDepartment of Physiology, The University of Melbourne bCentre for Chronic Disease, College of Health and Biomedicine, Victoria University, Melbourne, Australia.

Current Opinion in Nephrology and Hypertension
|July 2, 2016
PubMed
Summary

The endocannabinoid system, involving cannabinoid receptor 1 (CB1) and CB2, impacts kidney function. Targeting these receptors may treat kidney diseases like diabetic nephropathy and obesity-related conditions.

More Related Videos

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli
12:19

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli

Published on: June 27, 2015

11.7K
Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
10:15

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

2.3K

Related Experiment Videos

Last Updated: Mar 18, 2026

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
08:46

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

Published on: September 1, 2015

10.3K
Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli
12:19

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli

Published on: June 27, 2015

11.7K
Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
10:15

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

2.3K

Area of Science:

  • Nephrology
  • Endocrinology
  • Pharmacology

Background:

  • The endocannabinoid system regulates energy homeostasis through G protein-coupled receptors.
  • These receptors, including cannabinoid receptor 1 (CB1) and CB2, are present in the central nervous system and periphery, including the kidneys.

Purpose of the Study:

  • To review recent studies on the role of CB1 and CB2 in normal and pathological renal conditions.
  • To highlight the potential of modulating CB1 and CB2 activity as a therapeutic target for kidney diseases.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of studies involving isolated cells, rodent models, and human subjects.

Main Results:

  • CB1 and CB2 play significant roles in renal function and dysfunction.
  • Antagonism of CB1 and agonism of CB2 show potential in reducing albuminuria in diabetic nephropathy and obesity-associated kidney disease.
  • CB1 is upregulated in various models of human nephropathies, indicating a role in renal fibrosis.

Conclusions:

  • The endocannabinoid system is critical in renal function and disease.
  • Therapeutics targeting CB1 and CB2 activity in renal diseases may hold future clinical relevance.