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Sarcopenia associated with renal function in the patients with type 2 diabetes
Rongrong Yang1, Yongze Zhang1, Ximei Shen1
1Department of Endocrinology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian, China.
Diabetes Research and Clinical Practice
|July 2, 2016
Summary
Sarcopenia, or low muscle mass, is linked to reduced kidney function in type 2 diabetes patients. Higher muscle mass may lead to underestimation of kidney function markers.
Area of Science:
- Nephrology
- Endocrinology
- Geriatrics
Background:
- Low muscle mass (sarcopenia) is linked to declining kidney function in general populations.
- The relationship between sarcopenia and kidney function in type 2 diabetes (T2D) patients remains unclear.
Purpose of the Study:
- To investigate the association between sarcopenia and kidney function, specifically estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (UACR).
- To examine these associations in patients with type 2 diabetes.
Main Methods:
- Cross-sectional study comparing 793 individuals without diabetes and 762 individuals with type 2 diabetes.
- Assessment of appendicular skeletal muscle mass index (ASM/HT(2)), eGFR, and UACR.
Main Results:
- Non-sarcopenic individuals had higher ASM/HT(2) and eGFR, and lower UACR compared to sarcopenic individuals.
- ASM/HT(2) was significantly associated with eGFR in men without diabetes and showed a similar trend in women.
- ASM/HT(2) was associated with UACR in women across both groups.
- Higher ASM/HT(2) was linked to a greater risk of abnormal eGFR in the non-sarcopenic diabetic population.
Conclusions:
- Sarcopenia is associated with impaired kidney function, characterized by lower eGFR and higher UACR.
- In non-sarcopenic individuals, ASM/HT(2) is a risk factor for renal function, potentially due to muscle mass influencing creatinine and albumin estimations.
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