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EMT: 2016.

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Cell plasticity, including the epithelial-mesenchymal transition (EMT), drives embryonic development and disease. Understanding EMT

Keywords:
cancerdevelopmentepigeneticsepithelial-mesenchymal transitionfibrosismetastasisstemnesstherapeuticstranscriptional control

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Area of Science:

  • Cellular plasticity and developmental biology
  • Cancer research and pathology
  • Molecular and cellular biology

Background:

  • The epithelial-mesenchymal transition (EMT) is crucial in embryonic development and disease progression.
  • EMT is now understood as a spectrum of dynamic states, not a simple binary switch.
  • EMT and its intermediate states are implicated in organ fibrosis and tumor advancement.

Purpose of the Study:

  • To review the current understanding of cellular plasticity and heterogeneity in EMT.
  • To highlight recent findings and ongoing challenges in EMT research.
  • To discuss the implications of EMT in human diseases like cancer and fibrosis.

Main Methods:

  • Literature review and synthesis of current research on EMT.
  • Discussion of key concepts: cellular plasticity, heterogeneity, and transitional states.
  • Analysis of EMT's role in development, fibrosis, and cancer progression.

Main Results:

  • EMT represents a continuum of cellular states, not a single transition.
  • EMT and its intermediate states are key drivers of organ fibrosis and tumor progression.
  • The role of EMT in metastatic colonization requires careful interpretation.

Conclusions:

  • Cellular plasticity, particularly EMT, is fundamental to understanding complex diseases.
  • Further research is needed to address pending questions and overcome challenges in the EMT field.
  • Continued investigation into EMT heterogeneity and plasticity will advance disease treatment strategies.