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COPART Risk Score, Endothelial Dysfunction, and Arterial Hypertension are Independent Risk Factors for Mortality in

G Hackl1, P Jud1, A Avian2

  • 1Department of Internal Medicine, Division of Angiology, Medical University Graz, Austria.

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
|July 3, 2016
PubMed

Insights

The COPART risk score and flow-mediated dilation (FMD) predict mortality in peripheral artery disease patients. Combining these with arterial hypertension offers the best long-term survival assessment for claudicants.

Area of Science:

  • Vascular Medicine
  • Cardiovascular Research
  • Clinical Prognostics

Background:

  • Peripheral artery disease (PAOD) significantly impacts patient prognosis.
  • The COPART risk score is a tool for assessing PAOD patient outcomes.
  • Endothelial function, measured by flow-mediated dilation (FMD), is crucial for vascular health.

Purpose of the Study:

  • To evaluate the long-term mortality prediction capabilities of the COPART risk score and FMD in patients with intermittent claudication.
  • To determine the combined predictive value of these markers for disease-specific survival.

Main Methods:

  • A prospective observational study included 184 claudicants with a median follow-up of 7.9 years.
  • Brachial FMD was measured at study inclusion to assess endothelial function.
  • Patients were stratified into low, medium, and high risk groups based on the COPART risk score.

Main Results:

  • Overall survival rates significantly differed across COPART risk score groups (p < .001).
  • Survivors exhibited significantly better FMD compared to non-survivors (p < .001).
  • COPART risk score, FMD (≤2.5 vs. >2.5), and arterial hypertension were identified as independent predictors of long-term mortality.

Conclusions:

  • The COPART risk score, FMD, and arterial hypertension are significant independent predictors of long-term mortality in claudicants.
  • Integrating these three factors provides the most accurate mortality assessment for this patient group.
  • These findings support the use of a multi-factor approach for predicting long-term outcomes in PAOD.
Abstract

Keywords:
Arterial hypertensionCOPART risk scoreFlow mediated dilationMortalityPAOD

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