Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Impact: Problem Solving01:26

Impact: Problem Solving

491
In an experiment conducted during a Mars mission, a rover propels a projectile with an initial velocity, and the projectile rebounds after colliding with the Martian surface. To ascertain the maximum height attained by the projectile after this collision, the known restitution coefficient and acceleration due to gravity are employed.
By designating the launch point as the origin and utilizing kinematic equations, the vertical component of the projectile's velocity at the point of impact is...
491
Translocation of Proteins into the Mitochondria01:19

Translocation of Proteins into the Mitochondria

13.6K
Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
13.6K
Protein Transport into the Inner Mitochondrial Membrane01:34

Protein Transport into the Inner Mitochondrial Membrane

5.1K
Nuclear encoded mitochondrial precursors are imported to the inner membrane in a multistep process involving two separate translocons, TIM22 and TIM23. TIM23 is a cation-selective pore that remains closed by the N terminal segment of the protein. Negative charges on the TIM23 act as a receptor for the incoming precursor, pulling the positively charged matrix-targeting sequence for peptide insertion and translocation.
Transport of mitochondrial precursors across the TIM23 channel is driven by...
5.1K
Matrix-Assisted Laser Desorption Ionization (MALDI)01:08

Matrix-Assisted Laser Desorption Ionization (MALDI)

1.3K
Matrix-assisted laser desorption ionization (MALDI) is a powerful analytical technique used in mass spectrometry. It enables the identification and characterization of various biomolecules, including proteins, peptides, nucleic acids, and carbohydrates. MALDI is an ionization technique, widely employed in biological and medical research, as well as in fields like pharmacology and biochemistry.The analyte of interest, a biomolecule or a mixture of biomolecules, is mixed with a suitable matrix...
1.3K
Mitochondrial Protein Sorting01:39

Mitochondrial Protein Sorting

5.9K
Mitochondria are double-membrane organelles of the eukaryotes involved in cellular metabolism, signaling, ATP synthesis, and programmed cell death.  Each of these processes requires specific proteins and enzymes that must be correctly sorted to the right mitochondrial subcompartment for the proper functioning of the organelle.
Most of these mitochondrial proteins are encoded by the nucleus and imported to the mitochondria as unfolded or loosely folded precursors. Mitochondrial precursors...
5.9K
Mitochondrial Precursor Proteins01:39

Mitochondrial Precursor Proteins

3.9K
Mitochondrial precursors are partially unfolded or loosely folded polypeptide chains. Newly synthesized precursors are inhibited from spontaneously folding into their native conformation by the cytosolic chaperones, heat shock proteins 70 (Hsp70), and mitochondrial import stimulation factors (MSFs). Precursors bound to MSFs are guided to the TOM70-TOM37 receptors, while precursors bound to Hsp70  chaperones are targetted to TOM20-TOM22 receptor complexes.
Most of the mitochondrial...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Roadkill: An Opportunistic Strategy to Track PFAS in Venomous Snakes in a South African Urban Environment.

Archives of environmental contamination and toxicology·2026
Same author

Resting-state functional connectivity changes in the human brain from electrically-stimulated (2 Hz), rhythmic muscle contractions to the hand: An exploratory study.

Neuroimage. Reports·2025
Same author

Pathogenic POLE-Mutated Endometrial Carcinomas With a Nonultramutated Genome.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2025
Same author

Black mambas (Dendroaspis polylepis) as novel bioindicators of urban heavy metal pollution.

Environmental pollution (Barking, Essex : 1987)·2025
Same author

Social prescribing: Exploring general practitioners' and healthcare professionals' perceptions of, and engagement with, the NHS model.

Health & social care in the community·2022
Same author

Incorporation of Hydrophilic Macrocycles Into Drug-Linker Reagents Produces Antibody-Drug Conjugates With Enhanced <i>in vivo</i> Performance.

Frontiers in pharmacology·2022
Same journal

Compassion fatigue among critical care nurses: a literature review.

Nursing management (Harrow, London, England : 1994)·2026
Same journal

Repositioning entrepreneurial competence as a core nursing capability: unlocking nurses' leadership and innovation potential.

Nursing management (Harrow, London, England : 1994)·2026
Same journal

How to design and deliver a nurse fellowship.

Nursing management (Harrow, London, England : 1994)·2026
Same journal

Relationship between leadership transparency and workplace cynicism among nurses: a systematic review and meta-analysis.

Nursing management (Harrow, London, England : 1994)·2026
Same journal

Strengthening nurses' recognition of, and response to, domestic violence and abuse.

Nursing management (Harrow, London, England : 1994)·2026
Same journal

From strain to strength: enhancing the benefits of employing temporary nurses.

Nursing management (Harrow, London, England : 1994)·2026
See all related articles

Related Experiment Video

Updated: Mar 18, 2026

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity
09:38

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity

Published on: January 31, 2025

1.1K

Mission impossible?

Nick Evans

    Nursing Management (Harrow, London, England : 1994)
    |July 3, 2016
    PubMed
    Summary
    This summary is machine-generated.

    Nurses were recently called upon to lead change and assume additional frontline care responsibilities within a single 24-hour period. This highlights the evolving and expanding role of nursing professionals in healthcare.

    More Related Videos

    In Situ SIMS and IR Spectroscopy of Well-defined Surfaces Prepared by Soft Landing of Mass-selected Ions
    10:22

    In Situ SIMS and IR Spectroscopy of Well-defined Surfaces Prepared by Soft Landing of Mass-selected Ions

    Published on: June 16, 2014

    19.0K
    Real-time Video Projection in an MRI for Characterization of Neural Correlates Associated with Mirror Therapy for Phantom Limb Pain
    11:29

    Real-time Video Projection in an MRI for Characterization of Neural Correlates Associated with Mirror Therapy for Phantom Limb Pain

    Published on: April 20, 2019

    10.5K

    Related Experiment Videos

    Last Updated: Mar 18, 2026

    Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity
    09:38

    Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity

    Published on: January 31, 2025

    1.1K
    In Situ SIMS and IR Spectroscopy of Well-defined Surfaces Prepared by Soft Landing of Mass-selected Ions
    10:22

    In Situ SIMS and IR Spectroscopy of Well-defined Surfaces Prepared by Soft Landing of Mass-selected Ions

    Published on: June 16, 2014

    19.0K
    Real-time Video Projection in an MRI for Characterization of Neural Correlates Associated with Mirror Therapy for Phantom Limb Pain
    11:29

    Real-time Video Projection in an MRI for Characterization of Neural Correlates Associated with Mirror Therapy for Phantom Limb Pain

    Published on: April 20, 2019

    10.5K

    Area of Science:

    • Healthcare Management
    • Nursing Practice
    • Health Policy

    Background:

    • Recent policy documents have placed increased demands on nursing professionals.
    • Nurses are being asked to take on greater leadership and expanded frontline care roles.

    Purpose of the Study:

    • To analyze the implications of new demands on nursing roles.
    • To assess the capacity of nurses to lead change in healthcare settings.

    Main Methods:

    • Review of recent policy documents and calls to action.
    • Analysis of nursing scope of practice and leadership competencies.

    Main Results:

    • Two significant documents issued within 24 hours highlighted expanded nursing responsibilities.
    • These documents emphasize nurses' potential for leading change and frontline care innovation.

    Conclusions:

    • The nursing profession faces evolving expectations for leadership and advanced practice.
    • Healthcare systems should support nurses in assuming these expanded roles and responsibilities.