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Updated: Mar 18, 2026

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
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Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

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Polyphenol compounds and PKC signaling

Joydip Das1, Rashmi Ramani1, M Olufemi Suraju1

  • 1Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, United States.

Biochimica Et Biophysica Acta
|July 3, 2016
PubMed
Abstract

Insights

Polyphenols from food regulate protein kinase C (PKC) signaling pathways, impacting cellular processes and disease prevention, particularly cancer. Further research into these natural compounds may yield future cancer drugs.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Naturally occurring polyphenols possess significant health benefits, including potential in cancer prevention.
  • Polyphenols exert biological effects, partly by modulating protein kinase C (PKC) signaling pathways.
  • PKC, a serine-threonine kinase superfamily, regulates cellular processes via protein phosphorylation.

Purpose of the Study:

  • To provide a comprehensive review of polyphenol-PKC interactions.
  • To discuss the relevance of these interactions in various disease states, especially cancer.
  • To explore the future research perspectives in this field.

Main Methods:

  • Literature review of existing data on polyphenol-PKC interactions.
  • Analysis of the mechanisms by which polyphenols regulate PKC activity.
  • Discussion of isoform-specific and context-dependent regulation of PKC by polyphenols.

Main Results:

  • Polyphenols can regulate antioxidant enzyme gene transcription via PKC signaling.
  • PKC regulation by polyphenols is isoform-dependent and influenced by cellular context.
  • Curcumin and resveratrol are examples of polyphenols currently in clinical trials for colon cancer.

Conclusions:

  • Naturally occurring polyphenols show promise as anticancer agents, with 74% of cancer drugs originating from natural sources.
  • Polyphenols or their analogs may serve as future cancer therapeutics due to their ability to modulate PKC signaling.
  • Understanding polyphenol-PKC interactions is crucial for developing novel cancer treatments.
Keywords:
AntioxidantCancerPolyphenolProtein kinase CSignal transduction

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