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[Changes in the relaxation and compliance of the left ventricle in cardiomyopathy]

H K Li, W Z Ma, J Liao

    Zhonghua Nei Ke Za Zhi
    |January 1, 1989
    PubMed

    Insights

    Left ventricular diastolic function declines with age and is significantly impaired in dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), particularly in HCM. The A/D ratio aids in differentiating HCM from DCM.

    Area of Science:

    • Cardiology
    • Biomedical Engineering
    • Physiology

    Context:

    • Cardiomyopathy significantly impacts left ventricular diastolic function.
    • Accurate assessment of diastolic events is crucial for diagnosis and management.
    • Aging naturally affects left ventricular relaxation and compliance.

    Purpose:

    • To investigate left ventricular diastolic events in cardiomyopathy using multi-modal recordings.
    • To evaluate left ventricular relaxation and compliance in normal subjects and patients with DCM and HCM.
    • To compare diastolic dysfunction with systolic function in these conditions.

    Summary:

    • Simultaneous recordings of carotid pulse tracing, ECG, phonocardiogram, and apexcardiogram (with dA/dt) were performed in 240 normal subjects, 30 DCM patients, and 44 HCM patients.
    • Key diastolic parameters including Total Relaxation Time (TRT), TRT index (TRTI), A/D ratio, Diastolic Amplitude Time Index (DATI), and F/H ratio were measured.
    • Results show age-related decline in relaxation/compliance in normal subjects; significant decreases in DCM and especially HCM patients.
    • The A/D ratio, indicative of left ventricular compliance, was elevated in HCM compared to normal subjects and DCM patients, suggesting its diagnostic utility.
    • Systolic dysfunction, evidenced by abnormal PEP/LVET and R-dA/dt.I, was also observed in DCM patients.

    Impact:

    • This study provides insights into the distinct diastolic abnormalities in DCM and HCM.
    • The A/D ratio emerges as a potential diagnostic marker for differentiating HCM from DCM.
    • Findings highlight the combined diastolic and systolic dysfunction in DCM.

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