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[Oncogenic hypophosphatemic osteomalacia]
G Schultze1, G Delling, M Faensen
1Abteilung Nephrologie, Humboldt-Krankenhauses, Berlin.
Deutsche Medizinische Wochenschrift (1946)
|July 7, 1989
Summary
A rare mesenchymal phosphaturic tumor caused severe bone disease in a 51-year-old man. Treatment and surgery offered temporary relief, but the tumor recurred, highlighting the need for ongoing monitoring.
Area of Science:
- Endocrinology
- Oncology
- Orthopedics
Background:
- Hypophosphatemic osteomalacia can cause significant bone pain and fractures.
- Mesenchymal tumors can present with complex and varied clinical manifestations.
Observation:
- A 51-year-old male developed severe hypophosphatemic osteomalacia, motor impairment, and rib fractures over six years.
- Initial treatment with 1,25-dihydroxycholecalciferol, phosphorus, and calcium led to symptom improvement and normalized biochemical parameters.
- A highly vascularized mesenchymal phosphaturic tumor of hemangiopericytoma type was identified in the right femur.
Findings:
- Surgical removal of the tumor provided temporary symptom relief.
- Recurrence of bone pain necessitated resumption of medical treatment.
- Tumor regrowth in the right femoral condyle was detected via imaging two years post-surgery.
Implications:
- Mesenchymal phosphaturic tumors require vigilant monitoring due to potential for recurrence.
- Multidisciplinary management is crucial for patients with rare bone-affecting tumors.
- Early detection and intervention strategies for tumor recurrence remain critical.