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iPAD or PADi-'tablets' with therapeutic disease potential?
1Epinova Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GSK, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
Current Opinion in Chemical Biology
|July 4, 2016
Summary
Protein arginine deiminase (PAD) enzymes are increasingly linked to autoimmune diseases. PAD inhibitors show promise as a new therapeutic strategy for treating these conditions.
Area of Science:
- Biochemistry
- Immunology
- Pharmacology
Background:
- Protein arginine deiminase (PAD) enzymes play a role in citrullination.
- Citrullination is implicated in neutrophil extracellular trap formation and immune complex formation.
- PAD enzymes are increasingly recognized for their involvement in diverse diseases.
Purpose of the Study:
- To review the recent literature on PAD enzymes and their role in autoimmune diseases.
- To assess the therapeutic potential of PAD inhibitors.
Main Methods:
- Literature review of recent studies.
- Analysis of data from genetically deficient PAD2 or PAD4 mice models.
- Evaluation of PAD inhibitor development.
Main Results:
- Growing evidence supports the involvement of PAD enzymes in various diseases.
- PAD inhibitors and PAD-deficient mice models have accelerated research.
- The therapeutic potential of PAD inhibitors is confirmed.
Conclusions:
- PAD enzymes are critical targets for autoimmune disease treatment.
- PAD inhibitors represent a promising new class of drugs for human autoimmune diseases.
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