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Real-life experience with fampridine (Fampyra®) for patients with multiple sclerosis and gait disorders
Yara Dadalti Fragoso1, Tarso Adoni2, Soniza Vieira Alves-Leon3
1Department of Neurology, Universidade Metropolitana de Santos, Santos, SP, Brazil.
Background:
Fampridine is a broad-spectrum voltage-dependent potassium channel blocker that enhances synaptic transmission. The drug has been shown to be able to ameliorate conduction in demyelinated axons, thereby leading to improved gait in patients with multiple sclerosis (MS).
Objective:
To assess the "real-life" efficacy and safety of fampridine prescribed for gait disorders in MS. This was an observational and prospective study carried out at MS Units participating in the Brazilian Multiple Sclerosis Study Group.
Methods:
Patients with MS and gait disorders were prescribed fampridine (10 mg twice a day), irrespectively of the degree of disability determined by MS. Neurological disability determined by MS was assessed with the expanded disability scale score (EDSS). Outcomes for efficacy and safety of the drug were evaluated by the 25 foot-walk test and by the adverse events of fampridine.
Results:
The time taken to walk 25 feet decreased by 20% or more in 62 patients (70%). Twenty-five patients were considered to be non-responders to this treatment. Improvement in walking speed was independent of improvement of disability. Mild or moderate adverse events were reported in 8% of patients.
Conclusion:
Fampridine is an efficient and safe therapeutic option for patients with MS and gait disorders.
