Related Experiment Video
Updated: Mar 18, 2026
06:19
Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
Published on: September 9, 2022
4.8K
Annexin A2, autoimmunity, anxiety and depression
R Weiss1, A Bitton2, M Ben Shimon3
1Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Journal of Autoimmunity
|July 4, 2016
Summary
High levels of anti-Annexin A2 (ANXA2) antibodies in mice reduced anxiety and depression behaviors. This study established a novel animal model for antiphospholipid syndrome (APS) research.
Area of Science:
- Neuroimmunology
- Autoimmune Diseases
Background:
- Antiphospholipid syndrome (APS) is linked to neurological issues.
- Annexin A2 (ANXA2) is an autoantigen implicated in APS.
Purpose of the Study:
- To investigate the impact of high autoantibody levels against ANXA2 on the brain using a mouse model.
- To explore the role of the ANXA2-p11 complex in neurological manifestations of autoimmune diseases.
Main Methods:
- Mice were immunized with recombinant ANXA2 or adjuvant alone (control).
- Behavioral and cognitive tests were performed.
- Brain tissue was analyzed for ANXA2 IgG and protein expression (ANXA2, p11).
Main Results:
- High anti-ANXA2 antibody levels correlated with reduced anxiety and depression-like behaviors in mice.
- Significant reduction in serum corticosteroid levels was observed.
- Increased IgG and p11 expression were found in the brains of the ANXA2 group.
Conclusions:
- An animal model with high anti-ANXA2 antibodies demonstrated anxiolytic and anti-depressive effects.
- This model aids in understanding APS and the ANXA2-p11 complex's brain function.
Related Concept Videos
01:18Anxiety: Overview
1.3K
Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
1.3K
01:29Autoimmune Disorders
2.1K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
2.1K
01:30Generalized Anxiety Disorder
1.0K
Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...
1.0K
01:30Stress and Mental Health
1.1K
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
1.1K
01:19Psychoneuroimmunology: Diabetes and Cancer
600
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
600
01:28Social Anxiety Disorder
714
Social anxiety disorder, also known as social phobia, is characterized by an intense fear of social situations where one might face humiliation, rejection, embarrassment, or negative evaluation. This disorder leads individuals to avoid activities like casual conversations, public speaking, or seemingly simple tasks such as eating, signing documents, or swimming, in public settings. Its impact extends beyond discomfort, often significantly interfering with daily functioning and quality of life.
714