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Related Experiment Videos

Survival after negative second-look laparotomy.

D M Luesley1, K K Chan, F G Lawton

  • 1Department of Obstetrics and Gynaecology, Dudley Road Hospital, Birmingham.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|June 1, 1989
PubMed
Summary
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Complete pathological response in epithelial ovarian cancer is achievable but recurrence is common. Many patients achieving a negative second-look laparotomy still experience disease relapse, highlighting the need for improved treatment strategies.

Area of Science:

  • Oncology
  • Gynecologic Oncology
  • Cancer Research

Background:

  • Epithelial ovarian cancer (EOC) is a significant cause of cancer-related mortality in women.
  • Achieving a complete pathological response (pCR) is a critical treatment goal.
  • Second-look laparotomy with intraperitoneal biopsies assesses treatment effectiveness.

Purpose of the Study:

  • To evaluate the rate of complete pathological response in epithelial ovarian cancer patients treated with cisplatinum or irradiation.
  • To assess the rate of disease recurrence and survival following a negative second-look laparotomy in EOC patients.

Main Methods:

  • Retrospective analysis of 120 epithelial ovarian cancer patients.
  • Patients received high-dose single agent cisplatinum or total abdominal and pelvic irradiation.

Related Experiment Videos

  • Assessment of complete pathological response via multiple negative intraperitoneal biopsies at second-look laparotomy.

    • Main Results:

    • Complete pathological responses were observed in 22 out of 120 patients (18.3%).
    • Of 21 evaluable patients with a negative second-look laparotomy, 9 (43%) developed recurrent disease.
    • Median time to relapse was 15 months, with a median survival of 4 months post-relapse.

    Conclusions:

    • While complete pathological response can be achieved in epithelial ovarian cancer, a significant proportion of patients experience recurrence even after negative second-look laparotomy.
    • The findings underscore the aggressive nature of recurrent disease and the need for further research into more effective adjuvant therapies or surveillance strategies for high-risk patients.