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Structure and activation of pro-activin A

Xuelu Wang1, Gerhard Fischer1, Marko Hyvönen1

  • 1Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.

Nature Communications
|July 5, 2016
PubMed
Summary

Activin A activation was studied, revealing its precursor structure and how proteolysis unlocks its growth factor activity. The pro-domain remains bound but can be displaced by follistatin.

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