Related Experiment Video
Updated: Aug 4, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
[Changes in local blood flow in the solitary kidney after chronic blockade of cholinergic mediation]
Abstract:
The method of hydrogen clearance has been used to study the influence of compensatory hypertrophy and continuous 120-day pharmacologic blockade of parasympathetic nerves by atropine on interorgan peritubular blood circulation of the Wistar line rat kidneys. Reliable "lagging" of the cortical blood flow behind the analogous values of the control group with a single kidney is noted. Decrease of the cortex perfusion under conditions of cholinergic blockade is due to "baring" of the high sympathogenic tonus of cortical vessels in spite of postnephrectomic hyperperfusion in the control. A conclusion is made concerning significance of cholinergic mediation in development of compensatory hypertrophy of a single kidney in syndrome of its denervation impairment.
Related Concept Videos
Kidney Structure
Autoregulation of Blood Flow
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
Blood and Nerve Supply to the Kidney
Bloody Supply to the Kidneys:
The kidneys receive their blood supply from the renal arteries, which branch off from the abdominal aorta—the main artery supplying the abdomen and lower body. The renal arteries enter the kidneys at the hilum, a notch on the medial side of each...
Glomerular Filtration Rate and its Regulation
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
Acute Kidney Injury II: Pathophysiology

