Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

1.8K
The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
1.8K
Mass Analyzers: Overview01:13

Mass Analyzers: Overview

2.0K
The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
2.0K
Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

2.9K
Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
2.9K
Mass Spectrometers01:16

Mass Spectrometers

10.1K
This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:
10.1K
Mass Spectrometry: Complex Analysis01:21

Mass Spectrometry: Complex Analysis

2.0K
Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
2.0K
MALDI-TOF Mass Spectrometry01:19

MALDI-TOF Mass Spectrometry

7.4K
Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...
7.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Isolation, Identification, and Growth Promotion Effects of Plant Growth-Promoting Rhizobacteria on Alfalfa.

Microorganisms·2026
Same author

Detection of Pantoea ananatis in cerebrospinal fluid: a case report of central nervous system infection after craniotomy.

BMC infectious diseases·2026
Same author

Bayesian benchmark dose assessment of fluoride exposure and renal function impairment in adolescents.

International journal of environmental health research·2026
Same author

Integrating transcriptomic, physiological, and biochemical studies revealing the role of endogenous ABA and GA<sub>3</sub> in the germination of quinoa seed.

Frontiers in plant science·2026
Same author

Education as an upstream social security intervention: constructing a competency-based talent development framework in health economics.

Frontiers in public health·2026
Same author

Ubiquitination of MEIS1 by MDM2 serves as a switch for p53 stabilization and DNA damage response activation.

Cell death and differentiation·2026

Related Experiment Video

Updated: Mar 18, 2026

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry
07:33

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry

Published on: October 15, 2018

15.1K

Miniaturized Linear Wire Ion Trap Mass Analyzer.

Qinghao Wu1, Ailin Li1, Yuan Tian1

  • 1Department of Chemistry and Biochemistry, Brigham Young University , Provo, Utah 84602, United States.

Analytical Chemistry
|July 5, 2016
PubMed
Summary
This summary is machine-generated.

We developed a novel wire linear ion trap (LIT) for mass spectrometry. This cost-effective design offers high performance, with good agreement between simulation and experimental results for ion analysis.

More Related Videos

T-wave Ion Mobility-mass Spectrometry: Basic Experimental Procedures for Protein Complex Analysis
16:40

T-wave Ion Mobility-mass Spectrometry: Basic Experimental Procedures for Protein Complex Analysis

Published on: July 31, 2010

25.4K
Analyzing Large Protein Complexes by Structural Mass Spectrometry
15:35

Analyzing Large Protein Complexes by Structural Mass Spectrometry

Published on: June 19, 2010

25.0K

Related Experiment Videos

Last Updated: Mar 18, 2026

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry
07:33

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry

Published on: October 15, 2018

15.1K
T-wave Ion Mobility-mass Spectrometry: Basic Experimental Procedures for Protein Complex Analysis
16:40

T-wave Ion Mobility-mass Spectrometry: Basic Experimental Procedures for Protein Complex Analysis

Published on: July 31, 2010

25.4K
Analyzing Large Protein Complexes by Structural Mass Spectrometry
15:35

Analyzing Large Protein Complexes by Structural Mass Spectrometry

Published on: June 19, 2010

25.0K

Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry
  • Instrumentation

Background:

  • Traditional linear ion traps (LITs) often involve complex fabrication and assembly.
  • Optimizing electric field geometry is crucial for ion trap performance.
  • Accurate simulation and experimental validation are key for new instrument development.

Purpose of the Study:

  • To report a novel linear ion trap (LIT) design utilizing tensioned wires for electric field generation.
  • To validate the performance of the wire LIT through simulation and experimental comparison.
  • To assess the analytical capabilities, including resolution and limits of detection.

Main Methods:

  • Fabrication of a linear ion trap using tensioned wires positioned by drilled plastic end plates.
  • Computational simulation to optimize wire positions and predict performance.
  • Experimental validation using boundary ejection, stability diagrams, and mass spectrometry.
  • Determination of mass spectral peak widths (fwhm) and limits of detection (LOD) for benzene and toluene.

Main Results:

  • Good agreement was found between simulated and experimental stability diagrams and mass spectra.
  • Achieved mass spectral peak widths (fwhm) of approximately 0.38 Th at a scan rate of 3830 Th/s.
  • Demonstrated limits of detection of 137 ppbv for benzene and 401 ppbv for toluene.

Conclusions:

  • The wire linear ion trap (LIT) design is a viable and cost-effective alternative for mass spectrometry.
  • The design allows for easy scalability to different trap sizes.
  • The instrument exhibits high ion and photon transmission, low capacitance, and tolerance to assembly errors.