Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.6K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.6K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
Anatomy of the Eyeball01:20

Anatomy of the Eyeball

11.2K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
11.2K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.6K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Neural network based on modified simplex method and its application in studying forest self-thinning].

Ying yong sheng tai xue bao = The journal of applied ecology·2002
Same author

Autotransplantation of heart for repair of left ventricular rupture after mitral valve replacement.

Transplantation proceedings·2001
Same author

Histone tails modulate nucleosome mobility and regulate ATP-dependent nucleosome sliding by NURF.

Proceedings of the National Academy of Sciences of the United States of America·2001
Same author

[The intracellular signaling pathway initiated by ginsenosides in hematopoietic cells].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2001
Same author

[An epidemiological study on the factors influencing length of hospitalization for inpatients of burns].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2001
Same author

Sublethal cerebral ischemia inhibits caspase-3 activation induced by subsequent prolonged ischemia in the C57Black/Crj6 strain mouse.

Neuroscience letters·2001

Related Experiment Video

Updated: Mar 18, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.7K

[Microcirculation of optic nerve head and glaucoma].

S H Zhang1, J L Zhao, C Wu

  • 1Ophthalmology Department, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China.

[Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology
|July 5, 2016
PubMed
Summary

Glaucoma causes irreversible blindness, and its development is unclear. This review links reduced optic nerve head (ONH) microcirculation to glaucoma pathogenesis, providing evidence for its role in optic nerve damage.

More Related Videos

Doppler Optical Coherence Tomography of Retinal Circulation
10:46

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

19.3K
Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
08:55

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Published on: April 24, 2020

4.4K

Related Experiment Videos

Last Updated: Mar 18, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.7K
Doppler Optical Coherence Tomography of Retinal Circulation
10:46

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

19.3K
Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
08:55

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Published on: April 24, 2020

4.4K

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Microcirculation Research

Background:

  • Glaucoma is a primary cause of irreversible blindness globally.
  • The exact pathogenesis of glaucoma remains incompletely understood.
  • The role of optic nerve head (ONH) microcirculation in glaucoma is hypothesized but lacks direct evidence.

Purpose of the Study:

  • To review technical advancements in examining ONH blood flow.
  • To synthesize findings on the association between diminished ONH microcirculation and glaucoma.
  • To evaluate the evidence supporting ONH microcirculation's involvement in glaucoma.

Main Methods:

  • Literature review of studies on ONH blood flow examination techniques.
  • Analysis of research correlating ONH microcirculation status with glaucoma diagnosis and progression.
  • Synthesis of existing evidence linking microcirculatory changes to glaucomatous optic neuropathy.

Main Results:

  • Technical developments have improved the assessment of ONH blood flow.
  • Multiple studies indicate a correlation between reduced ONH microcirculation and glaucoma.
  • Evidence suggests that impaired ONH microcirculation is a contributing factor in glaucoma development.

Conclusions:

  • Damaged ONH microcirculation is implicated in the pathogenesis of glaucoma.
  • Further research into ONH hemodynamics may offer new insights into glaucoma treatment.
  • Understanding microcirculatory dysfunction is crucial for addressing glaucoma-related vision loss.