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Retinoic Acid Modulates PTGDR Promoter Activity.

A García-Sánchez1,2, E Marcos-Vadillo2,3, C Sanz2,4

  • 11Department of Biomedical and Diagnostic Science, University of Salamanca, Salamanca, Spain.

Journal of Investigational Allergology & Clinical Immunology
|July 5, 2016
PubMed
Summary
This summary is machine-generated.

Retinoic acid (RA) activates the PTGDR gene promoter, a key player in allergic diseases. This finding suggests potential new treatments for allergies and asthma based on modulating PTGDR activity, considering genetic variations.

Keywords:
Allergic asthmaPTGDRPolymorphismsRetinoic acid

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Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • Vitamin A metabolites, including retinoic acid (RA), are implicated in allergic disease development.
  • The prostaglandin receptor PTGDR is a candidate gene for allergy and asthma, potentially linked to RA via the prostaglandin pathway.

Purpose of the Study:

  • To investigate the effect of retinoic acid (RA) on the activation of the PTGDR gene promoter.
  • To explore the role of PTGDR in the context of allergic diseases and RA signaling.

Main Methods:

  • A549 lung epithelial cells were transfected with PTGDR promoter variants and treated with all-trans RA (ATRA).
  • Luciferase assays and real-time quantitative PCR were used to measure gene expression and promoter activity.
  • In silico analysis identified potential RA response elements in the PTGDR promoter.

Main Results:

  • ATRA treatment significantly increased PTGDR promoter activity (P<.001).
  • Expression of CYP26A1 and RARB genes increased 12-fold and 4-fold, respectively, after ATRA treatment.
  • In silico analysis confirmed the presence of RA response elements within the PTGDR promoter region.

Conclusions:

  • Retinoic acid (RA) modulates PTGDR gene promoter activity.
  • The effectiveness of RA and potential new PTGDR-targeting therapies may depend on the genetic background of allergic asthma patients.