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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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Related Experiment Video

Updated: Mar 18, 2026

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
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Aging clinical problems: a difficult balance between age and frailty.

Renzo Rozzini1

  • 1Fondazione Poliambulanza, Istituto Ospedaliero. renzo.rozzini@poliambulanza.it.

Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace
|July 5, 2016
PubMed
Summary

Frailty is a geriatric syndrome increasing older adults' risk of health decline. Understanding frailty helps geriatricians and public health experts improve elder resilience and health outcomes.

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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Area of Science:

  • Gerontology
  • Geriatric Medicine
  • Public Health

Background:

  • Frailty is a common geriatric syndrome in older adults.
  • It is characterized by weakness, reduced energy, and unintended weight loss.
  • Frailty increases vulnerability to stressors like infections and extreme temperatures.

Purpose of the Study:

  • To understand the factors contributing to frailty in older adults.
  • To identify beneficial interventions for frailty.
  • To explore the link between frailty and physiological system regulation.

Main Methods:

  • Empirical assessment of geriatric frailty in individuals.
  • Focus on identifying features related to frailty.
  • Analysis of physiological system regulation.

Main Results:

  • Frailty reflects impaired regulation of multiple physiological systems.
  • It signifies a lack of resilience to physiological challenges.
  • This lack of resilience elevates the risk of adverse health outcomes.

Conclusions:

  • Frailty is a key geriatric syndrome with significant health implications.
  • Understanding frailty is crucial for geriatricians and public health.
  • Interventions targeting frailty can improve elder health and function.