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Related Experiment Video

Updated: Mar 18, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
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Resistance training and sarcopenia.

Francesco Giallauria1, Antonio Cittadini, Neil Andrew Smart

  • 1Federico II University of Naples. giallauriafrancesco@gmail.com.

Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace
|July 5, 2016
PubMed
Summary

Aging causes muscle loss (sarcopenia), worsened by inactivity and poor nutrition. Resistance exercise is key, and new interventions targeting muscle gene expression and protein turnover are needed to maintain muscle function in older adults.

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Area of Science:

  • Gerontology
  • Muscle Physiology
  • Sarcopenia Research

Background:

  • Aging leads to a natural decline in muscle mass, quality, and strength, a condition known as sarcopenia.
  • Factors like hormonal changes, inactivity, poor nutrition, illness, and nervous system decline accelerate age-related sarcopenia.
  • The precise molecular mechanisms driving sarcopenia remain incompletely understood.

Purpose of the Study:

  • To review current understanding of age-related muscle decline (sarcopenia).
  • To discuss exercise interventions, particularly resistance training, for mitigating sarcopenia.
  • To explore novel therapeutic strategies for preventing muscle atrophy and promoting muscle growth in aging populations.

Main Methods:

  • Literature review of aging, sarcopenia, and muscle physiology.
  • Analysis of the impact of various risk factors on muscle health.
  • Discussion of exercise physiology and emerging molecular targets for intervention.

Main Results:

  • Resistance exercise is the most effective intervention for improving muscle mass and strength in older adults.
  • Understanding age-related changes in gene expression, protein synthesis, and turnover is critical for developing new treatments.
  • Several risk factors contribute to sarcopenia, but their downstream effects require further elucidation.

Conclusions:

  • Sarcopenia is a significant consequence of aging, influenced by multiple factors.
  • Exercise, especially resistance training, is vital for combating sarcopenia.
  • Further research into molecular mechanisms is essential for innovative therapeutic approaches to maintain muscle function during aging.