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Related Concept Videos

Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

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Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
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Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

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Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
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Lipids: Dietary Sources and Requirements01:18

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Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
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Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

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Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
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Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

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Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Related Experiment Video

Updated: Mar 18, 2026

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
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Cholesterol: until which age 'the lower the better'?

Niccolò Marchionni1, Francesco Orso

  • 1Università di Firenze. niccolo.marchionni@unifi.it.

Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace
|July 5, 2016
PubMed
Summary

The prognostic role of high cholesterol in the elderly is unclear, with conflicting data. This review assesses hypercholesterolemia

Area of Science:

  • Gerontology
  • Cardiology
  • Public Health

Background:

  • The prognostic significance of hypercholesterolemia in the elderly, especially the very elderly, remains uncertain.
  • Conflicting literature exists regarding the association between high cholesterol levels and cardiovascular events in older adults.
  • Some studies suggest a link between low cholesterol levels and increased mortality risk in the very elderly.

Purpose of the Study:

  • To assess the prognostic role of hypercholesterolemia in elderly patients.
  • To evaluate the impact of reducing hypercholesterolemia in elderly individuals for both primary and secondary prevention.
  • To address uncertainties in hypercholesterolemia treatment for the elderly due to trial exclusions.

Main Methods:

  • Literature review and critical analysis of existing studies.

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  • Examination of data concerning cardiovascular events and mortality in elderly populations.
  • Assessment of treatment guidelines and evidence for hypercholesterolemia management in older adults.

    • Main Results:

    • Evidence suggests a complex relationship between cholesterol levels and outcomes in the elderly.
    • The benefits of cholesterol reduction in the elderly, particularly in primary prevention, require further investigation.
    • Exclusion of elderly individuals from clinical trials complicates treatment recommendations.

    Conclusions:

    • The prognostic value of hypercholesterolemia and the efficacy of its reduction in the elderly are not definitively established.
    • Further research is needed to clarify the risks and benefits of managing hypercholesterolemia in older populations.
    • Clinical guidelines for elderly patients may need refinement based on emerging evidence.