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Rescuing cardiac automaticity in L-type Cav1.3 channelopathies and beyond

Pietro Mesirca1,2,3, Isabelle Bidaud4,5,6, Matteo E Mangoni7,8,9

  • 1Département de Physiologie, Institut de Genomique Fonctionnelle, LabEx ICST, UMR-5203, Centre national de la recherche scientifique, F-34094, Montpellier, France. pietro.mesirca@igf.cnrs.fr.

The Journal of Physiology
|July 5, 2016
PubMed
Summary

Sick sinus syndrome (SSS) causes slow heart rate and is treated with pacemakers. Targeting compensatory ion channels, like IKACh, may offer new therapies for SSS and bradycardia.

Keywords:
Cav1.3 channelsGirk4 channelsHCN4 channelscardiac electrophysiologypacemaker activitysick sinus syndromesino-atrial node

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