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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...

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Related Experiment Video

Updated: Mar 18, 2026

Isolation of Murine Intestinal Mesenchyme Resulting in a High Yield of Telocytes

Isolation of Murine Intestinal Mesenchyme Resulting in a High Yield of Telocytes

Published on: March 24, 2023

Singling Out Intestinal Epithelial Stem Cells

Pauline K Lund¹, Michael P Verzi²

¹Department of Cell Biology and Physiology and Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Gastroenterology

|July 5, 2016

Summary

No abstract available in PubMed .

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