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Emerging hydrogel designs for controlled protein delivery

Ki Hyun Bae1, Motoichi Kurisawa

  • 1Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore. mkurisawa@ibn.a-star.edu.sg.

Biomaterials Science
|July 5, 2016
PubMed

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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