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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Emerging hydrogel designs for controlled protein delivery.

Ki Hyun Bae¹, Motoichi Kurisawa

¹Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore. mkurisawa@ibn.a-star.edu.sg.

Biomaterials Science

|July 5, 2016

Summary

Recent advances in hydrogel design enable controlled release of bioactive proteins for drug delivery and regenerative medicine. New enzyme-responsive, externally regulated, and phase-separated hydrogel systems show promise for expanded biomedical applications.

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Area of Science:

Biomaterials Science
Drug Delivery Systems
Regenerative Medicine

Background:

Hydrogels are crucial biomaterials in drug delivery and regenerative medicine.
Controlled release of bioactive proteins remains a key challenge.

Purpose of the Study:

To review recent advances in hydrogel design for controlled release of bioactive proteins.
To summarize novel enzyme-responsive and externally regulated hydrogel systems.
To describe design strategies and applications of phase-separated hydrogel systems.

Main Methods:

Literature review of recent advancements in hydrogel design.
Focus on enzyme-responsive and externally regulated systems.
Analysis of phase-separated hydrogel strategies.

Main Results:

Recent hydrogel designs offer enhanced control over bioactive protein release.
Enzyme-responsive and externally regulated systems demonstrate significant progress.
Phase-separated hydrogels present versatile design and application opportunities.

Conclusions:

Emerging hydrogel approaches are poised to expand their use in biomedicine and healthcare.
Advanced hydrogel designs facilitate precise control over protein therapeutics.
Continued innovation in hydrogel biomaterials will drive therapeutic advancements.