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Reference Intervals of Hematology and Clinical Chemistry Analytes for 1-Year-Old Korean Children

Hye Ryun Lee1,2, Sue Shin3,4,5, Jong Hyun Yoon3,4,6

  • 1Department of Laboratory Medicine, Sheikh Khalifa Specialty Hospital, Ras Al Khaimah, United Arab Emirates.

Annals of Laboratory Medicine
|July 5, 2016
PubMed

Insights

Reference intervals for healthy 1-year-olds were established for hematology and chemistry. Formula-fed infants showed higher iron status markers compared to breastfed infants, highlighting feeding method impacts on iron levels.

Area of Science:

  • Pediatric Medicine
  • Clinical Chemistry
  • Hematology

Background:

  • Establishing age-specific reference intervals is crucial for accurate health assessments.
  • Previous research indicates the need for pediatric reference ranges, particularly for 1-year-olds.
  • Infant feeding practices can significantly influence nutritional status, including iron levels.

Purpose of the Study:

  • To establish reference intervals for hematology and clinical chemistry analytes in healthy 1-year-old children.
  • To analyze the impact of infant feeding methods (breast milk vs. formula) on iron status markers in this age group.

Main Methods:

  • 887 children underwent medical check-ups; 534 healthy children were selected as reference individuals.
  • Hematology and clinical chemistry analytes were measured, with reference values determined using parametric and nonparametric methods.
  • Iron, total iron-binding capacity, and ferritin were measured; transferrin saturation was calculated to assess iron status.

Main Results:

  • Reference intervals were established for 1-year-olds, with no significant differences observed between sexes.
  • Children fed formula exclusively or mainly exhibited higher serum iron, ferritin, and transferrin saturation levels.
  • These findings suggest a differential impact of feeding methods on iron metabolism during infancy.

Conclusions:

  • Established reference intervals for hematology and clinical chemistry provide a valuable tool for evaluating 1-year-old children.
  • The study highlights the importance of considering feeding methods when interpreting iron status in infants.
  • These reference intervals aid in the interpretation of medical check-up results for one-year-olds.
Abstract

Keywords:
1-Year-OldChemistryFeedingHematologyReference interval

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