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Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
Published on: November 10, 2021
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Extracellular vesicles in renal tissue damage and regeneration
Stefania Bruno1, Stefano Porta1, Benedetta Bussolati1
1Department of Biotechnology and Health Sciences, Molecular Biotechnology Center; University of Turin, Italy.
European Journal of Pharmacology
|July 5, 2016
Summary
Extracellular vesicles (EVs) are key in cell communication and show regenerative potential for kidney injury. This review explores their therapeutic applications in renal regenerative medicine.
Area of Science:
- Cell biology
- Regenerative medicine
- Nephrology
Background:
- Extracellular vesicles (EVs) mediate cell-to-cell communication through their protein and RNA cargo.
- Urinary EVs play a role in inter-nephron communication, with potential impacts on kidney health.
- EVs from mesenchymal stromal cells (MSCs) show promise as cell-free therapeutics, mimicking stem cell effects.
Purpose of the Study:
- To review the effects of EVs in repairing acute and chronic kidney injury.
- To discuss the underlying mechanisms of EV-mediated renal repair.
- To analyze strategies, benefits, and limitations of using EVs in renal regenerative medicine.
Main Methods:
- Review of preclinical data on EV administration in renal damage models.
- Analysis of studies investigating EV content and function in kidney repair.
- Examination of therapeutic strategies for EV application in nephrology.
Main Results:
- Preclinical data suggest EVs from various MSC sources possess regenerative potential for renal damage.
- EVs have demonstrated therapeutic effects in models of both acute and chronic kidney injury.
- Mechanisms of EV action in renal repair are being elucidated, highlighting their complex roles.
Conclusions:
- EVs hold significant promise as a cell-free therapeutic strategy for renal regenerative medicine.
- Further research is needed to optimize EV-based therapies and understand their full potential and limitations.
- EVs represent a viable therapeutic avenue for treating kidney diseases.
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