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Updated: Mar 18, 2026
Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station INBEST
Published on: April 23, 2015
Peromyscus as a model of human disease
Amanda Havighorst1, Janet Crossland2, Hippokratis Kiaris3
1Department of Drug Discovery and Biomedical Sciences, University of South Carolina, SC, USA; Peromyscus Genetic Stock Center, Office of Research, University of South Carolina, SC, USA.
Abstract:
Animals of the genus Peromyscus have been a particularly informative model for many areas of study, including behavior, evolution, anatomy, physiology and genetics. While their use in modeling human disease and pathology has been relatively restricted, certain qualities of Peromyscine mice may make them a good candidate for such studies. Pathophysiological conditions where Peromyscus may be of particular value involve aging, reactive oxygen species-associated pathologies, metabolism and detoxification, diabetes, and certain cancers. In this review article we will summarize pathological conditions where Peromyscus have been used effectively, we will discuss factors limiting the use of Peromyscus in studying pathology and we will indicate areas at which the use of this model may be of special value.
Insights
Peromyscus mice, often used in genetics and evolution studies, show promise for modeling human diseases like diabetes and cancer. Their unique physiology makes them valuable for aging and metabolism research.
Area of Science:
- Zoology
- Genetics
- Pathology
Background:
- Peromyscus mice are established models in behavior, evolution, anatomy, physiology, and genetics.
- Their application in human disease and pathology research is less explored but holds potential.
Purpose of the Study:
- To review the effective use of Peromyscus in pathological studies.
- To identify limitations and future opportunities for Peromyscus in pathology research.
Main Methods:
- Literature review of studies utilizing Peromyscus for pathological research.
- Analysis of Peromyscus characteristics relevant to disease modeling.
Main Results:
- Peromyscus have been effectively used in studies of aging, oxidative stress, metabolism, diabetes, and cancer.
- Factors limiting their use in pathology include availability and specific research infrastructure.
Conclusions:
- Peromyscus offer a valuable, yet underutilized, model for investigating specific human pathophysiological conditions.
- Further research leveraging Peromyscus could advance understanding of aging, metabolic disorders, and cancer.
