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Collecting reliable clades using the Greedy Strict Consensus Merger.

Markus Fleischauer1, Sebastian Böcker1

  • 1Lehrstuhl für Bioinformatik, Friedrich-Schiller Universität , Jena , Thüringen , Germany.

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|July 5, 2016
PubMed
Summary

Supertree methods reconstruct large phylogenetic trees. New scoring functions for the Greedy Strict Consensus Merger (GSCM) improve clade discovery by 18%, enhancing supertree resolution.

Keywords:
ConsensusDivide and ConquerFlipCutPhylogenySupermatrixSupertree

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Area of Science:

  • Computational phylogenetics
  • Bioinformatics
  • Evolutionary biology

Background:

  • Supertree methods integrate multiple phylogenetic trees into a single, comprehensive tree.
  • These methods offer an alternative to computationally intensive phylogenetic inference, aiding in reconstructing the Tree of Life.
  • Existing supertree approaches face challenges with conflicting data and can be improved by identifying known clades.

Purpose of the Study:

  • To enhance the Greedy Strict Consensus Merger (GSCM) for improved clade discovery in supertree construction.
  • To evaluate novel scoring functions and randomization techniques for GSCM preprocessing.
  • To increase the resolution and accuracy of supertrees generated using the Superfine approach.

Main Methods:

  • Development and application of novel scoring functions for the Greedy Strict Consensus Merger (GSCM).
  • Introduction of a randomization strategy to augment GSCM's clade identification capabilities.
  • Integration of improved GSCM results into the Superfine supertree construction framework.

Main Results:

  • The modified GSCM, utilizing new scoring functions and randomization, significantly increases the number of true positive clades identified.
  • A performance improvement of 18% in true positive clade discovery was observed compared to the standard Overlap scoring.
  • Enhanced clade discovery directly contributes to improved resolution in the final supertree.

Conclusions:

  • Novel scoring functions and randomization effectively enhance the Greedy Strict Consensus Merger (GSCM) for supertree construction.
  • The improved GSCM preprocessing step leads to more accurate and resolved phylogenetic supertrees.
  • This work provides a valuable advancement for reconstructing large-scale evolutionary histories.