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Emerging Roles of the Mitogen and Stress Activated Kinases MSK1 and MSK2

Kathleen M S E Reyskens1, J Simon C Arthur1

  • 1Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee Dundee, UK.

Frontiers in Cell and Developmental Biology
|July 5, 2016
PubMed

Insights

Mitogen- and stress-activated kinases (MSKs) 1 and 2 regulate gene expression in immune and neuronal cells. This review highlights their anti-inflammatory roles and involvement in central nervous system functions like synaptic plasticity.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Neuroscience

Background:

  • Mitogen- and stress-activated kinases (MSKs) 1 and 2 are key nuclear kinases.
  • They are activated by ERK1/2 and p38 MAPK pathways.
  • MSKs regulate gene expression through phosphorylation of substrates like CREB and Histone H3.

Purpose of the Study:

  • To review recent advances in understanding MSK1 and MSK2 functions.
  • Focus on their roles in the innate immune system and neuronal function.

Main Methods:

  • Literature review of studies on MSK1 and MSK2.
  • Analysis of their roles in immune and neuronal cell signaling pathways.

Main Results:

  • MSKs play predominantly anti-inflammatory roles in immunity, regulating IL-10 production.
  • In the central nervous system (CNS), MSKs are involved in neuronal proliferation and synaptic plasticity.

Conclusions:

  • MSKs are critical regulators in both innate immunity and CNS function.
  • Further research into MSKs can elucidate novel therapeutic targets for inflammatory and neurological disorders.
Keywords:
CREBIL-10MAPKMSK1MSK2innate immunityp38synaptic plasticity

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