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Bladder Cancer Molecular Taxonomy: Summary from a Consensus Meeting
Seth P Lerner1, David J McConkey2, Katherine A Hoadley3
1Scott Department of Urology, Dan L. Duncan Cancer Center, Baylor College of Medicine , Houston, TX, USA.
Bladder Cancer (Amsterdam, Netherlands)
|July 5, 2016
Summary
Researchers reached a consensus on a Basal-Squamous-like (BASQ) subtype of urothelial bladder cancer, characterized by specific gene expression. Further research is needed to define other subtypes molecularly.
Area of Science:
- Oncology
- Genomics
- Molecular Biology
Background:
- Omics technologies are crucial for molecular subtyping of urothelial bladder cancer.
- Previous studies show partially overlapping findings in cancer subclassification.
- A consensus meeting was convened to discuss and harmonize classification strategies.
Purpose of the Study:
- To discuss existing molecular classifications of urothelial bladder cancer.
- To reach a consensus on tumor subtypes.
- To identify areas requiring further molecular definition.
Main Methods:
- Presentations of updated research from participating teams.
- Discussion and consensus-building on molecular classifications.
- Analysis of gene expression patterns (e.g., KRT5/6, KRT14, FOXA1, GATA3).
Main Results:
- Consensus reached on a Basal-Squamous-like (BASQ) tumor group.
- BASQ tumors show high KRT5/6 and KRT14 expression, low FOXA1 and GATA3.
- An additional subgroup with urothelial differentiation features was identified, needing further definition.
Conclusions:
- A distinct BASQ molecular subtype of urothelial bladder cancer is recognized.
- Optimal molecular definition for other identified subtypes requires further investigation.
- Harmonization of urothelial bladder cancer classification is an ongoing process.
