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Using Analytic Morphomics to Understand Short-Term Convalescence after Radical Cystectomy.
Amy N Luckenbaugh1, Brent K Hollenbeck1, Jeffrey S Montgomery1
1Department of Urology, University of Michigan Medical School , Ann Arbor, MI, USA.
Bladder Cancer (Amsterdam, Netherlands)
|July 5, 2016
Summary
Preoperative psoas muscle area may predict recovery after radical cystectomy, particularly for women. Higher muscle mass correlated with better pain recovery and faster activity return in female patients.
Area of Science:
- Urology
- Surgical Oncology
- Radiology
Background:
- Preoperative imaging data may predict surgical risk.
- Psoas muscle area (PMA) is a morphometric parameter.
- Analytic morphomics utilizes imaging data to assess patient risk.
Purpose of the Study:
- To investigate the association between PMA and short-term recovery after radical cystectomy.
- To determine if PMA can predict patient convalescence following cystectomy.
Main Methods:
- Retrospective analysis of patients undergoing radical cystectomy (2008-2013).
- PMA calculated from staging CT scans using analytic morphomic techniques.
- Early recovery assessed using the Convalescence and Recovery Evaluation (CARE) questionnaire.
Main Results:
- Median PMA differed significantly between men and women (2,544 mm² vs. 1,511 mm²).
- No association found between PMA and recovery in men.
- Women with higher PMA showed less postoperative pain decrease and faster return to baseline activity levels.
Conclusions:
- PMA is a potential preoperative predictor of recovery in women undergoing radical cystectomy.
- Analytic morphomics offers a novel approach to understanding perioperative risk.
