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Advances in PET/MR instrumentation and image reconstruction
Jorge Cabello1, Sibylle I Ziegler1
1Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
The British Journal of Radiology
|July 5, 2016
Summary
Positron emission tomography (PET) and MRI combination enables advanced imaging. This review covers hardware, software, and applications of simultaneous PET/MRI in research and clinical settings.
Area of Science:
- Medical Imaging
- Biomedical Engineering
- Radiochemistry
Background:
- The integration of Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) has gained significant traction over the past two decades.
- Initially focused on small-animal imaging, PET/MRI technology has recently expanded into clinical research applications.
- This hybrid imaging modality offers unique advantages for exploring complex biological and medical questions.
Purpose of the Study:
- To provide an overview of simultaneous PET/MRI technology.
- To discuss the technological advancements in both hardware and software for PET/MRI systems.
- To highlight exemplar applications of this combined imaging technique in research and clinical settings.
Main Methods:
- Review of research developments in PET instrumentation compatible with MRI environments.
- Description of hardware solutions addressing electromagnetic field interference.
- Overview of software algorithms for attenuation correction, motion correction, and quantitative image reconstruction, including parametric modeling.
- Inclusion of preclinical and clinical experimental findings and commercial scanner information.
Main Results:
- Significant progress has been made in developing PET instrumentation that can coexist with MRI's electromagnetic fields.
- Advanced software algorithms have been developed to overcome challenges like attenuation correction and leverage MRI for motion correction.
- Simultaneous PET/MRI has demonstrated potential across various research fields, enabling novel insights.
- Commercial PET/MRI scanners are now available, facilitating broader adoption.
Conclusions:
- Simultaneous PET/MRI represents a powerful tool for advancing medical research and clinical diagnostics.
- Ongoing technological innovations in hardware and software continue to enhance the capabilities of PET/MRI systems.
- The synergistic combination of PET and MRI opens new avenues for quantitative imaging and understanding disease kinetics.
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