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Hemophagocytic Lymphohistiocytosis in a Young Child

Uma Nahar Saikia1, Anju Gupta, Pandiarajan Vignesh

  • 1Departments of Pediatrics, *Histopathology and #Virology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Correspondence to: Dr Anju Gupta, Additional Professor, Department of Pediatrics Postgraduate Institute of Medical Education and Research, Chandigarh, India. anjupgi@gmail.com.

Indian Pediatrics
|July 5, 2016
PubMed

Hemophagocytic lymphohistiocytosis (HLH) is a multisystem disorder mediated by cytokine storm and is characterized by fever, pancytopenia and organomegaly coupled with laboratory features like hyperferritinemia, hypertriglyceridemia, hypofibrinogenemia and transaminitis. Etiology can be genetic or acquired such as infections, malignancy and autoimmune disorders. Diagnosis, identification of underlying etiology and management of HLH remain tough clinical puzzles to sort out for the managing physician. We report a clinico-pathological conference of a three-year-old boy who had such a presentation and succumbed during the hospital stay.

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