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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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Noncoding RNAs Regulating p53 and c-Myc Signaling

Yide Mei1, Mian Wu2

  • 1CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, 230027, China.

Advances in Experimental Medicine and Biology
|July 5, 2016
PubMed

Insights

This chapter reviews noncoding RNAs, including microRNAs and long noncoding RNAs, that regulate tumor suppressors like p53 and proto-oncogenes like c-Myc. Understanding these interactions is crucial for cancer research and clinical applications.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Genetics

Background:

  • p53 is a critical tumor suppressor, while c-Myc is a proto-oncogene frequently activated in human cancers.
  • Both p53 and c-Myc are central regulators of cellular processes and decision-making.
  • Dysregulation of p53 and c-Myc pathways is implicated in tumorigenesis.

Purpose of the Study:

  • To comprehensively review the role of noncoding RNAs in regulating p53 and c-Myc.
  • To highlight recent advancements in understanding noncoding RNA involvement in p53 and c-Myc networks.
  • To discuss the implications of these regulatory mechanisms in basic science and clinical settings.

Main Methods:

  • Literature review of recently published studies on noncoding RNAs.
  • Analysis of microRNAs and long noncoding RNAs acting as regulators and effectors for p53 and c-Myc.
  • Examination of intracellular and extracellular pathways involved in these regulations.

Main Results:

  • Noncoding RNAs, including microRNAs and long noncoding RNAs, are significant regulators of p53 and c-Myc.
  • These noncoding RNAs modulate the complex network of cis-elements and transfactors affecting p53 and c-Myc.
  • Recent research demonstrates diverse mechanisms by which noncoding RNAs influence p53 and c-Myc activity.

Conclusions:

  • Noncoding RNAs play a pivotal role in the intricate regulatory network of p53 and c-Myc.
  • Further investigation into noncoding RNA functions offers potential for novel therapeutic strategies in cancer.
  • Understanding these interactions is key to advancing both fundamental cancer biology and clinical oncology.
Keywords:
Noncoding RNAc-MycmiRNAp53

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