Related Experiment Video
Updated: Mar 18, 2026
07:08
Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
Published on: August 31, 2022
2.1K
Radiation Recall Dermatitis Secondary to Dactinomycin
Brea Prindaville1, Kimberly A Horii2, Kristi M Canty2
1Division of Dermatology, Children's Mercy-Kansas City, Kansas City, Missouri. brea.prindaville@alum.dartmouth.org.
Pediatric Dermatology
|July 6, 2016
Summary
Radiation recall dermatitis (RRD) is a rare reaction to chemotherapy after radiation. This case highlights RRD in a pediatric patient treated with dactinomycin, emphasizing early recognition.
Area of Science:
- Oncology
- Dermatology
- Pediatric Medicine
Background:
- Radiation recall dermatitis (RRD) is an uncommon adverse reaction to radiation therapy.
- It typically manifests as skin inflammation within previously irradiated areas.
- Chemotherapeutic agents are the most common triggers for RRD.
Observation:
- RRD is rarely documented in pediatric patients.
- This report details a case in a 15-month-old boy.
- The patient developed RRD following dactinomycin treatment.
Findings:
- Dactinomycin, a chemotherapy agent, can induce radiation recall dermatitis.
- The presentation involved dermatitis within the radiation port.
- Internal organ involvement is a potential complication of RRD.
Implications:
- Early recognition of RRD is crucial due to potential systemic involvement.
- This case expands the understanding of RRD in pediatric oncology.
- Awareness of RRD is important for managing pediatric cancer patients undergoing radiation therapy.
Related Concept Videos
01:18Other Unique Bacteria
529
Magnetic bacteria exhibit a directed movement called magnetotaxis, driven by structures called magnetosomes. These magnetosomes consist of chains of magnetic particles made of either magnetite (Fe₃O₄) or greigite (Fe₃S₄) and are organized in a linear conformation by a protein scaffold within invaginations of the cell membrane. The bacteria align along the north–south magnetic field lines, much like a compass needle. They are typically microaerophilic or anaerobic...
529
01:30Drug Toxicity: Allergic Reactions
106
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
106
01:35Mutations
45.3K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
45.3K
01:30Skin Cancer
6.5K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.5K
01:29Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
136
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
136
01:38Nucleotide Excision Repair
5.6K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
5.6K