Lifestyle in Multiple Myeloma - a longitudinal cohort study protocol
M Heinrich1, A Fisher2, B Paton3
1Health Behaviour Research Centre, Department of Epidemiology and Public Health, University College London, London, UK.
BMC Cancer
|July 6, 2016
Summary
This study investigates physical activity and fitness in Multiple Myeloma (MM) patients, finding it impacts bone health and quality of life. Objective measures will guide future exercise interventions for better patient outcomes.
Area of Science:
- Oncology
- Exercise Physiology
- Bone Health Research
Background:
- Multiple Myeloma (MM) significantly impacts bone health, causing pain and fatigue, thus reducing quality of life.
- While physical activity benefits solid tumor patients, its role in MM requires further objective investigation.
- Understanding the link between physical fitness and quality of life in MM patients is crucial.
Purpose of the Study:
- To objectively and longitudinally assess physical activity and fitness levels in Multiple Myeloma patients.
- To explore the association between physical fitness, bone health, fatigue, and quality of life in MM.
- To identify optimal timing for physical activity interventions within the MM patient journey.
Main Methods:
- Prospective cohort study design involving MM patients in remission.
- Assessment of physical activity, fatigue, and bone health at baseline and 3, 6, 12 months.
- Utilized objective measures like cardiopulmonary exercise testing (CPET) and accelerometry alongside self-report measures.
Main Results:
- This section is not available in the provided abstract.
Conclusions:
- This study is the first to prospectively and longitudinally examine physical fitness associations in MM using objective measures.
- Findings will illuminate the role of fitness in MM patient well-being, bone health, and fatigue.
- Identifies key time points for implementing physical activity interventions to maximize benefits for MM patients.
Related Concept Videos
02:20Longitudinal Research
13.6K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.6K
01:26Longitudinal Studies
617
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
617
01:15Bioavailability Study Design: Healthy Subjects Versus Patients
201
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
201
01:11Bioavailability Study Design: Single Versus Multiple Dose Studies
318
Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
318
01:21Cancer Survival Analysis
812
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
812
01:20Lifestyle Factors and Health
582
Lifestyle factors play a critical role in maintaining overall health and preventing chronic diseases. Key elements, such as regular physical activity, a nutritious diet, and abstinence from smoking, can significantly enhance physical, mental, and emotional well-being while reducing the risk of several life-threatening conditions.
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
582