Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glycosaminoglycans01:23

Glycosaminoglycans

7.6K
Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
7.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Isolation of Yersinia enterocolitica From a Sea Turtle: A Case Report in Caretta caretta.

Veterinary medicine and science·2026
Same author

Nanofibers of polyester-polydopamine copolymers enable combined photothermal effect and chemotherapy for local cancer treatment.

International journal of pharmaceutics·2026
Same author

Eco-Friendly Fabrication of Secretome-Loaded, Glutathione-Extended Waterborne Polyurethane Nanofibers.

International journal of molecular sciences·2025
Same author

Smart Theranostic Nanogels with Swelling-Driven Contrast for Multimodal Imaging, Sensing, and Photothermal Breast Cancer Ablation.

Advanced healthcare materials·2025
Same author

The dynamic regenerative scaffold stenting and shielding hernia system for dissection-free, atraumatic hernioplasty. Results of an experimental animal study.

Scientific reports·2025
Same author

Development and characterization of injectable, bioadhesive, pH-responsive hyaluronic acid-based hydrogels for enhanced postoperative cancer therapy.

International journal of pharmaceutics·2025

Related Experiment Video

Updated: Mar 18, 2026

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

12.0K

Hyaluronic Acid Derivative with Improved Versatility for Processing and Biological Functionalization.

Fabio S Palumbo1, Stefano Agnello2, Calogero Fiorica2

  • 1Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche, Sezione di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Palermo, Via Archirafi 32, 90123, Palermo, Italy. fabiosalvatore.palumbo@unipa.it.

Macromolecular Bioscience
|July 6, 2016
PubMed
Summary

This study presents a novel hyaluronic acid derivative (HA-EDA-C18) for creating porous scaffolds without chemical crosslinking. These versatile scaffolds support cell growth and controlled drug release for tissue engineering applications.

Keywords:
RGDcollagen type IIdexamethasonedrug releasehyaluronic acid derivativesmaleimide chemistry

More Related Videos

Hyaluronic-Acid Based Hydrogels for 3-Dimensional Culture of Patient-Derived Glioblastoma Cells
08:35

Hyaluronic-Acid Based Hydrogels for 3-Dimensional Culture of Patient-Derived Glioblastoma Cells

Published on: August 24, 2018

13.7K
Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
15:33

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

29.9K

Related Experiment Videos

Last Updated: Mar 18, 2026

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

12.0K
Hyaluronic-Acid Based Hydrogels for 3-Dimensional Culture of Patient-Derived Glioblastoma Cells
08:35

Hyaluronic-Acid Based Hydrogels for 3-Dimensional Culture of Patient-Derived Glioblastoma Cells

Published on: August 24, 2018

13.7K
Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
15:33

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

29.9K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Drug Delivery

Background:

  • Hyaluronic acid (HA) is a biocompatible polymer with potential in regenerative medicine.
  • Developing HA-based scaffolds with enhanced properties and functionalities is crucial for advanced applications.
  • Existing methods often require chemical crosslinking, which can introduce cytotoxicity.

Purpose of the Study:

  • To develop a versatile, chemically crosslink-free porous scaffold from a modified hyaluronic acid derivative (HA-EDA-C18).
  • To demonstrate the scaffold's capability for biological functionalization, including peptide tethering and drug loading/release.
  • To evaluate the scaffold's performance in supporting chondrocyte behavior for cartilage tissue engineering.

Main Methods:

  • Fabrication of porous HA-EDA-C18 scaffolds using a salt leaching technique.
  • Chemical modification to tether thiol-bearing RGD peptide for enhanced cell adhesion.
  • Loading and in vitro release studies of dexamethasone as a model drug.
  • Assessment of scaffold swelling and degradation behavior.
  • Evaluation of bovine chondrocyte metabolic activity, proliferation, and collagen type II production.

Main Results:

  • Successfully fabricated crosslink-free porous HA-EDA-C18 scaffolds with controlled architecture.
  • Demonstrated efficient tethering of RGD peptides and controlled release of dexamethasone.
  • Scaffolds exhibited favorable swelling and degradation profiles.
  • Significant cellular adhesion, proliferation, and collagen type II production by chondrocytes cultured on the scaffolds.

Conclusions:

  • HA-EDA-C18 is a versatile material for fabricating functional porous scaffolds without chemical crosslinking.
  • These scaffolds show great promise for cartilage tissue engineering by supporting chondrocyte function.
  • The developed platform allows for tunable biological functionalization and controlled drug delivery.