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Updated: Mar 18, 2026
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Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes
Published on: September 27, 2014
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Ebola Virus Epidemiology and Evolution in Nigeria
Onikepe A Folarin1, Deborah Ehichioya1, Stephen F Schaffner2
1Department of Biological Sciences African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State.
The Journal of Infectious Diseases
|July 6, 2016
Summary
Effective containment limited the 2014 Nigerian Ebola virus (EBOV) outbreak. Genomic data confirmed a single source, distinct lineage, and no international spread from Nigeria.
Area of Science:
- * Epidemiology
- * Viral genomics
- * Infectious disease outbreak analysis
Background:
- * The 2014 Ebola virus (EBOV) outbreak in Nigeria was contained, resulting in 20 reported cases.
- * Understanding the transmission dynamics and genetic origins of this outbreak is crucial for public health preparedness.
Purpose of the Study:
- * To present clinical and contact tracing data for the Nigerian EBOV outbreak.
- * To analyze full-length EBOV genome sequences to reconstruct transmission patterns.
- * To determine the origin and potential spread of the Nigerian EBOV lineage.
Main Methods:
- * Collection and analysis of clinical data and contact information for EBOV case patients.
- * Whole-genome sequencing of EBOV from Nigerian isolates.
- * Phylogenetic analysis to reconstruct the transmission tree and compare genomic data.
Main Results:
- * Detailed contact data enabled near-complete reconstruction of the outbreak's transmission tree.
- * Genomic data confirmed a single introduction source for the Nigerian outbreak.
- * The Nigerian EBOV lineage is genetically distinct from, but nested within, a Liberian lineage; no evidence of international transmission from Nigeria was found.
Conclusions:
- * Containment strategies were effective in limiting the Nigerian EBOV outbreak.
- * Phylogenetic and epidemiological data confirm a single origin and limited geographic spread.
- * The Nigerian EBOV strain represents a distinct genetic lineage with no onward international transmission.
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