Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Extracellular Matrix01:29

The Extracellular Matrix

13.1K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
13.1K
The Extracellular Matrix01:42

The Extracellular Matrix

90.8K
Overview
90.8K
Extracellular Matrix01:26

Extracellular Matrix

6.4K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
6.4K
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

9.6K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
9.6K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

3.7K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
3.7K
Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

3.6K
Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Membrane Tubulation by Cytoskeletal System: From Physical Principles to Cellular Mechanisms and In Vitro Reconstitution.

Journal of oleo science·2026
Same author

A framework for building a synthetic cell from the SynCell Asia Initiative.

Nature biotechnology·2026
Same author

Millimeter-Scale Dual-Opposing RNA-Gradient Hydrogel for Interfacial Gene Silencing.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Instant Membrane Stabilization by Damage-Triggered Actin Polymerization in Giant Unilamellar Vesicles.

Chembiochem : a European journal of chemical biology·2026
Same author

Beyond Human Variability: Deep Learning for Intravascular Ultrasound Segmentation With Noisy Labels.

Ultrasound in medicine & biology·2026
Same author

Extracellular Matrix-Coated Vesicles as a Biomimetic Model of MembraneMatrix Interplay.

Small methods·2025

Related Experiment Video

Updated: Mar 18, 2026

Production of Extracellular Matrix Fibers via Sacrificial Hollow Fiber Membrane Cell Culture
06:01

Production of Extracellular Matrix Fibers via Sacrificial Hollow Fiber Membrane Cell Culture

Published on: February 2, 2019

8.0K

Erratum: Extracellular Matrix Revisited: Roles in Tissue Engineering.

Youhwan Kim1, Hyojin Ko1, Ik Keun Kwon2

  • 1Department of Chemistry and Institute of Biological Interfaces, Sogang University, Seoul, Korea.

International Neurourology Journal
|July 6, 2016
PubMed
Summary

This study corrects a previous publication. The correction pertains to information presented on page S23 of volume 20, identified by PMID: 27230457.

More Related Videos

Fabricating a Kidney Cortex Extracellular Matrix-Derived Hydrogel
08:23

Fabricating a Kidney Cortex Extracellular Matrix-Derived Hydrogel

Published on: October 13, 2018

11.0K
A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix
09:40

A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix

Published on: January 4, 2017

17.5K

Related Experiment Videos

Last Updated: Mar 18, 2026

Production of Extracellular Matrix Fibers via Sacrificial Hollow Fiber Membrane Cell Culture
06:01

Production of Extracellular Matrix Fibers via Sacrificial Hollow Fiber Membrane Cell Culture

Published on: February 2, 2019

8.0K
Fabricating a Kidney Cortex Extracellular Matrix-Derived Hydrogel
08:23

Fabricating a Kidney Cortex Extracellular Matrix-Derived Hydrogel

Published on: October 13, 2018

11.0K
A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix
09:40

A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix

Published on: January 4, 2017

17.5K

Area of Science:

  • Scientific publishing
  • Academic errata
  • Scholarly communication

Context:

  • Correction of published scientific literature
  • Ensuring accuracy in research records
  • Maintaining integrity of scientific archives

Purpose:

  • To rectify an error in a previously published article
  • To provide accurate information to the scientific community
  • To update the official record of scientific findings

Summary:

  • A specific correction is issued for an article published in volume 20
  • The correction is located on page S23
  • The article is identified by its PubMed ID (PMID: 27230457)

Impact:

  • Improves the reliability of the scientific record
  • Prevents the dissemination of incorrect information
  • Facilitates accurate citation and referencing