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Related Experiment Video

Updated: Mar 18, 2026

A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva

A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva

Published on: July 5, 2017

Ageing and ocular surface immunity.

Alireza Mashaghi¹, Jiaxu Hong¹, Sunil K Chauhan¹

¹Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.

The British Journal of Ophthalmology

|July 6, 2016

Summary

This summary is machine-generated.

Ocular surface immunopathologies increase with age due to immune dysregulation. This review examines ocular immune aging, comparing it to other tissues and discussing its role in dry eye disease and infectious keratitis.

Keywords:

Immunology Infection Inflammation Ocular surface

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Area of Science:

Immunology
Ophthalmology
Gerontology

Background:

Ocular surface immunopathologies are more prevalent in the elderly.
Age-related immune dysregulation, affecting both innate and adaptive responses, is linked to this increased prevalence.
Ocular surface immune aging shares similarities and differences with other mucosal tissues.

Purpose of the Study:

To review key findings in ocular immune aging.
To compare age-related changes in ocular immunity with other mucosal tissues.
To discuss the role of age-related immune changes in infectious keratitis and dry eye disease.

Main Methods:

Literature review of ocular immune aging.
Comparative analysis of ocular and mucosal tissue immune responses.
Discussion of immunopathogenesis in common ocular surface disorders.

Main Results:

The elderly exhibit enhanced ocular surface immunopathologies.
Age-related immune dysregulation impacts ocular surface immunity.
Ocular immune aging patterns are comparable to other mucosal sites.

Conclusions:

Age-related immune changes significantly affect the ocular surface.
Understanding these changes is crucial for managing inflammatory eye conditions like dry eye and infectious keratitis in older adults.