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Cardiovascular Response Patterns to Sympathetic Stimulation by Central Hypovolemia
Anne-Sophie G T Bronzwaer1, Jasper Verbree2, Wim J Stok3
1Department of Internal Medicine, Academic Medical Center, University of AmsterdamAmsterdam, Netherlands; Laboratory for Clinical Cardiovascular Physiology, Center for Heart Failure Research, Academic Medical CenterAmsterdam, Netherlands.
Frontiers in Physiology
|July 6, 2016
Summary
Healthy individuals show distinct, reproducible cardiovascular responses to sympathetic stimulation. These patterns, related to baroreflex sensitivity and heart rate, highlight individual differences in autonomic blood pressure control.
Area of Science:
- Cardiovascular Physiology
- Autonomic Nervous System Regulation
- Human Physiology
Background:
- Cardiovascular responses to sympathetic stimulation vary significantly among healthy individuals.
- Understanding the consistency and reproducibility of these individual variations is crucial for interpreting physiological responses.
Purpose of the Study:
- To investigate whether inter-subject variations in cardiovascular responses to lower body negative pressure (LBNP) are consistent and reproducible within individuals.
- To identify potential factors influencing distinct cardiovascular response patterns.
Main Methods:
- Continuous hemodynamic monitoring and time-domain baroreflex sensitivity (BRS) assessment in 10 healthy subjects.
- Three consecutive 5-minute runs of lower body negative pressure (LBNP) at -50 mmHg, repeated after one week to assess reproducibility.
Main Results:
- Two distinct patterns of cardiovascular response to LBNP were observed: one group showed a prominent heart rate increase, while the other exhibited a significant rise in total peripheral resistance.
- These distinct response patterns were associated with differences in resting baroreflex sensitivity and resting heart rate.
- The observed cardiovascular response patterns were highly reproducible within individual subjects over time.
Conclusions:
- Distinct and reproducible cardiovascular response patterns to sympathetic stimulation via LBNP exist in young healthy individuals.
- These preferential autonomic blood pressure control patterns appear linked to baseline baroreflex sensitivity and heart rate.
- Individual differences in autonomic regulation manifest as consistent, distinct physiological responses.
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