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Updated: Mar 18, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
[Extracorporeal lung support-news and future developments]
1Universitätsklinik für Innere Medizin I, Intensivstation 13.i2, Allgemeines Krankenhaus der Stadt Wien/Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich. thomas.staudinger@meduniwien.ac.at.
Abstract:
Technical developments as well as the experiences during the 2009 influenza pandemia have led to an increased and safer use of extracorporeal gas exchange. Indications are expanding as new systems with the main goal of CO2 elimination have entered the market, thus, broadening the range of systems in addition to classic "high flow" extracorporeal membrane oxygenation (ECMO), although evidence for many suggested indications is sparse or lacking. However, recent research has shed light into the pathophysiology and interaction between the organism and the extracorporeal systems. Upcoming indications like avoiding intubation and mechanical ventilation or reducing invasiveness of ventilation are being evaluated. Novel data and technical advances will keep perspectives of extracorporeal gas exchange dynamic and exciting.

