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Related Experiment Video

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Emerging biomarkers in systemic sclerosis.

Mirko Manetti1

  • 1Department of Experimental and Clinical Medicine, Section of Anatomy and Histology, University of Florence, Florence, Italy.

Current Opinion in Rheumatology
|July 6, 2016
PubMed
Summary
This summary is machine-generated.

New biomarkers for systemic sclerosis (SSc) show promise for improving diagnosis and treatment. While many candidate biomarkers have been identified, further validation is needed for clinical use and precision medicine in SSc.

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Area of Science:

  • Rheumatology
  • Immunology
  • Genetics

Background:

  • Systemic sclerosis (SSc) presents significant heterogeneity in organ involvement, disease progression, and treatment response.
  • Biomarker discovery is crucial for identifying disease risk, enhancing early diagnosis, and refining prognostic assessments in SSc.
  • Understanding SSc's pathogenic mechanisms is essential for developing effective therapeutic strategies.

Purpose of the Study:

  • To review recent advancements in biomarker development for systemic sclerosis (SSc).
  • To highlight the potential of novel biomarkers in improving SSc patient management and clinical trial design.

Main Methods:

  • Utilizing traditional and next-generation techniques, including transcriptomic, epigenomic, and proteomic analyses.
  • Identifying candidate biomarkers correlated with distinct SSc clinical phenotypes.

Main Results:

  • Numerous candidate biomarkers have emerged from large-scale molecular analyses, linking to various SSc clinical presentations.
  • Skin gene expression-based pharmacodynamic biomarkers show potential as surrogate measures for clinical endpoints, such as the modified Rodnan skin thickness score.
  • These biomarkers offer objective assessment of treatment response in clinical trials.

Conclusions:

  • Promising biomarkers for SSc have been identified, addressing critical needs in patient evaluation and management.
  • Rigorous validation in prospective studies is necessary before these biomarkers can be integrated into clinical practice.
  • The development of robust, ideally mechanistic, biomarkers is essential for advancing precision medicine in SSc.