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Caspase-3 in serum predicts outcome after aneurysmal subarachnoid hemorrhage

Jie Wang1, Jian-Feng Wang1, Xiao-Ming Hu1

  • 1Department of Neurosurgery, Taizhou Hospital of Zhejiang Province, 150 Ximen Street, Linhai 317000, PR China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|July 7, 2016
PubMed

Insights

Elevated serum caspase-3 activities correlate with aneurysmal subarachnoid hemorrhage (aSAH) severity and poor prognosis. These caspase-3 levels can predict outcomes, offering a potential biomarker for aSAH patients.

Area of Science:

  • Biomarkers in Neurology
  • Apoptosis Research
  • Neurocritical Care

Background:

  • Caspase-3 is a key enzyme in apoptosis, making it a potential indicator of cellular damage.
  • Aneurysmal subarachnoid hemorrhage (aSAH) is a critical neurological condition with significant morbidity and mortality.
  • Understanding markers of disease severity and prognosis in aSAH is crucial for patient management.

Purpose of the Study:

  • To investigate the temporal changes in serum caspase-3 activity following aSAH.
  • To analyze the relationship between serum caspase-3 activity and the severity of aSAH.
  • To evaluate the predictive value of serum caspase-3 activity for patient outcomes after aSAH.

Main Methods:

  • Serum caspase-3 activities were measured in 118 controls and 118 aSAH patients at various time points (admission, days 1, 2, 3, 5, 7).
  • Comparisons were made based on time to blood sampling, World Federation of Neurological Surgeons (WFNS) scores, and modified Fisher scores.
  • Six-month outcomes were assessed using the Glasgow Outcome Scale (GOS).

Main Results:

  • Serum caspase-3 activities were significantly elevated in aSAH patients compared to controls, peaking on day 3 post-hemorrhage.
  • Higher caspase-3 levels were observed in patients with unfavorable outcomes (GOS 1-3), correlating with WFNS and modified Fisher scores.
  • Admission and day 3 caspase-3 activities independently predicted poor outcomes, even after adjusting for age and severity scores.

Conclusions:

  • Increased serum caspase-3 activity is strongly associated with aSAH severity.
  • Serum caspase-3 activity serves as a valuable prognostic marker for aSAH.
  • Caspase-3 warrants further investigation as a potential therapeutic target or diagnostic tool in aSAH.
Abstract

Keywords:
Aneurysmal subarachnoid hemorrhageCaspase-3PrognosisSeverity

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