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Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...

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Updated: Mar 18, 2026

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Published on: May 4, 2018

Dental mesenchymal stem cells.

Paul T Sharpe¹

¹Department of Craniofacial Development and Stem Cell Biology, Dental Institute, Kings College London, London SE1 9RT, UK paul.sharpe@kcl.ac.uk.

Development (Cambridge, England)

|July 7, 2016

Summary

This summary is machine-generated.

Mammalian teeth contain mesenchymal stem cells (MSCs) that can regenerate dental tissues. Research highlights their potential for developing novel stem cell therapies for dental disorders.

Keywords:

Dental Incisor MSCs Pulp Teeth

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Area of Science:

Stem Cell Biology
Regenerative Medicine
Dental Research

Background:

Mesenchymal stem cells (MSCs) reside in mammalian teeth, playing a role in tooth development and repair.
Dental MSCs exhibit characteristics similar to bone marrow-derived MSCs in vitro, including self-renewal and differentiation potential.
Teeth offer an accessible source of MSCs and a model for studying stem cell behavior in vivo.

Purpose of the Study:

To review recent advancements in understanding dental MSC function and behavior.
To explore the potential of dental MSCs for developing new biologically based dental therapies.
To discuss the clinical relevance and accessibility of teeth as a source for stem cell treatments.

Main Methods:

Review of current literature on dental mesenchymal stem cells.
Analysis of in vitro characteristics and in vivo functions of dental MSCs.
Discussion of recent discoveries and their implications for regenerative dentistry.

Main Results:

Dental MSCs demonstrate multipotency, differentiating into osteoblasts, chondrocytes, and adipocytes.
Teeth provide a readily accessible and clinically relevant source of MSCs.
Recent research highlights the therapeutic potential of dental MSCs for various dental conditions.

Conclusions:

Dental MSCs are a promising source for regenerative therapies in dentistry.
Further research into dental MSC behavior will drive the development of novel treatments.
The accessibility and properties of dental MSCs position them as key players in future dental medicine.