Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of High-emergency Lung Transplantation Procedure on 1-y Survival in France.

Transplantation·2026
Same author

Maturity Onset Diabetes of the Young (MODY): French National Diagnosis and Care Protocol (PNDS, Protocole National de Diagnostic et de Soins).

Orphanet journal of rare diseases·2026
Same author

Impact of high intensity physical activity compared to routine counseling on renal function decline in patients with type 2 diabetes at high risk for kidney disease - the ACTIDIANE randomized controlled trial.

Diabetes & metabolism·2026
Same author

Pulmonary indications for heart-lung transplantation: A modified Delphi survey among the French transplantation community.

JHLT open·2026
Same author

New Islet Model for 3D Study of Endothelial and β Cell Interactions: Relevance for the Screening of Cytoprotective Agents.

Journal of visualized experiments : JoVE·2026
Same author

C-terminal α<sub>1</sub>-antitrypsin peptides as pre-transplant biomarkers for chronic lung allograft dysfunction risk stratification.

ERJ open research·2026

Related Experiment Video

Updated: Mar 18, 2026

Artificial Lung Device Priming for In Situ Fiber Bundle Surface Grafting
08:53

Artificial Lung Device Priming for In Situ Fiber Bundle Surface Grafting

Published on: March 28, 2025

845

Microparticles: A new insight into lung primary graft dysfunction?

Anne Olland1, Jérémie Reeb1, Alexandre Leclerq1

  • 1Lung Transplantation Group, University Hospital Strasbourg, Strasbourg France; EA 7293 SVTT 'Stress Vasculaire et Tissulaire en Transplantation', Translational Medecine Federation, University of Strasbourg, Strasbourg, France.

Human Immunology
|July 7, 2016
PubMed
Summary

Researchers identified microparticles as potential early markers for lung ischemia reperfusion injury. This could help predict primary graft dysfunction after lung transplantation, improving patient outcomes.

Keywords:
BiomarkerExperimentalIschemia reperfusion injuryLung allograftMicroparticles

More Related Videos

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis
07:52

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Published on: December 21, 2014

10.6K
Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation
06:15

Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation

Published on: November 10, 2023

1.5K

Related Experiment Videos

Last Updated: Mar 18, 2026

Artificial Lung Device Priming for In Situ Fiber Bundle Surface Grafting
08:53

Artificial Lung Device Priming for In Situ Fiber Bundle Surface Grafting

Published on: March 28, 2025

845
Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis
07:52

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Published on: December 21, 2014

10.6K
Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation
06:15

Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation

Published on: November 10, 2023

1.5K

Area of Science:

  • Cardiovascular and Respiratory System Science
  • Transplantation Immunology
  • Biomarker Discovery

Background:

  • Primary graft dysfunction (PGD) significantly impacts lung transplant outcomes, often stemming from ischemia reperfusion injury (IRI).
  • Current methods lack early markers to assess IRI extent and predict PGD development.
  • Microparticles, released from stressed cells, are implicated in tissue injury and remodeling.

Purpose of the Study:

  • To investigate the potential of microparticles as early diagnostic markers for lung IRI.
  • To explore microparticle utility in predicting PGD following lung transplantation.

Main Methods:

  • Utilized ex-vivo lung reperfusion models to induce and study IRI.
  • Analyzed alveolar microparticles as indicators of IRI severity.
  • Proposed microparticle analysis for clinical application in transplant assessment.

Main Results:

  • Alveolar microparticles were identified as surrogate markers for significant IRI in experimental models.
  • Microparticle levels correlate with the extent of lung ischemia injury.

Conclusions:

  • Microparticles show promise as early, non-invasive biomarkers for lung IRI.
  • Assessing microparticles could aid in predicting PGD and optimizing lung transplant management.