Related Experiment Video
Updated: Mar 18, 2026
A Mouse Model of Pulmonary Fibrosis Induced by Nasal Bleomycin Nebulization
Published on: January 20, 2023
Protective roles of polysaccharides from Ganoderma lucidum on bleomycin-induced pulmonary fibrosis in rats
Jianhui Chen1, Yingying Shi2, Lian He3
1Department of Respiratory Medicine, Xiangya Hospital of Central South University, Key Site of National Clinical Research Center for Respiratory Disease, Changsha 410008, PR China; Department of Respiratory Medicine, Huai'an Second People's Hospital, Huai'an 223002, Jiangsu, PR China.
Abstract:
The purpose of this paper was to investigate the protective effects of polysaccharides from (PGL) Ganoderma lucidum on bleomycin-induced pulmonary fibrosis in rats. Our study demonstrated that treatment with PGL of 100-300mg/kg for 28 days led to significant reduction in the pulmonary index, inflammatory cell infiltration and collagen deposition in rats with bleomycin-induced pulmonary fibrosis, which was associated with increased levels of glutathione, glutathione peroxidase, catalase and superoxide dismutase and decreased contents of malondialdehyde and hydroxyproline in the lung. These results indicated that PGL played a positive protective role in the pulmonary fibrosis and its possible mechanism was to improve lung antioxidant ability.
