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Efficacy of adoptive cellular therapy in patients with gastric cancer: a meta-analysis
Dong Shen1, Zhi-Hao Liu1, Jia-Ning Xu2
1Institute for Health Education, Jiangsu Provincial Center for Disease Control & Prevention, 172 Jiangsu Road, Nanjing 210009, P.R. China.
Aim:
To systemically evaluate the efficacy and safety of adoptive cellular therapy for the treatment of gastric cancer (GC).
Materials & Methods:
We performed a systemic review and meta-analysis of nine eligible trials with GC and evaluated the effect of adoptive cellular therapy on the overall survival (OS) rate, T-cell subsets and adverse events.
Results:
Overall, 829 patients were involved in the analysis. Adoptive cellular therapy significantly improved the OS rate compared with the control group. Meanwhile, we observed greatly increased percentages of CD3(+), CD4(+) and CD4(+)/CD8(+) in cellular therapy groups.
Conclusion:
Adoptive cellular therapy combined with adjuvant therapy resulted in significantly better OS rates, progression-free survival and T-lymphocyte responses in patients with GC.
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