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Allergen immunotherapy for IgE-mediated food allergy: protocol for a systematic review
Sangeeta Dhami1, Ulugbek Nurmatov2, Giovanni Battista Pajno3
1Evidence-Based Health Care Ltd, Edinburgh, UK.
Background:
The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated food allergy. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in IgE-mediated food allergy.
Methods:
We will undertake a systematic review, which will involve searching international biomedical databases for published, in progress and unpublished evidence. Studies will be independently screened against pre-defined eligibility criteria and critically appraised using established instruments. Data will be descriptively and, if possible and appropriate, quantitatively synthesised.
Discussion:
The findings from this review will be used to inform the development of recommendations for EAACI's Guidelines on AIT.
